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Tocris Bioscience™ AC 187

Potent and selective amylin antagonist

Brand:  Tocris Bioscience™ 3419/500U

Product Code. 18034502

  • £301.00 / 500µg

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Description

Description

AC 187 is an orally active, potent amylin receptor antagonist (IC50 = 0.48 nM) that displays 38-fold and 400-fold selectivity over calcitonin and CGRP receptors respectively. Blocks amyloid β-induced neurotoxicity by attenuating the activation of initiator and effector caspases in vitro. Increases glucagon secretion, accelerates gastric emptying, alters plasma glucose levels and increases food intake in vivo.
Specifications

Specifications

0.95
Store at -20°C
500 μg
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