TPEN, Tocris Bioscience™

Description

Cell-permeable Zn2+ chelator; also inhibits RNA binding protein Lin28

Heavy metal chelator. Reacts with both Zn-proteome and Zn-metallothionein (MT) in LLC-PK1 cells; acts as an intracellular chelator of proteomic Zn2+. Activity decreases intracellular zinc levels, and induces apoptosis in HeLa and cultured human retinal pigment epithelium (RPE) cells. Also inhibits RNA binding protein Lin28 (IC50 = 2.5 μM). Cell permeable.

Specifications

• CAS: 16858-02-9
• Molecular Formula: C26H28N6
• MDL Number: MFCD00036918
• Quantity: 100 mg
• Synonym: tpen, n,n,n',n'-tetrakis 2-pyridylmethyl ethylenediamine, n1,n1,n2,n2-tetrakis pyridin-2-ylmethyl ethane-1,2-diamine, unii-r9ptu1u29i, n,n,n',n'-tetrakis 2-pyridylmethyl ethane-1,2-diamine, r9ptu1u29i, n,n,n',n'-tetrakis 2-pyridyl-methyl ethylenediamine, 1,2-ethanediamine, n,n,n',n'-tetrakis 2-pyridinylmethyl-, oc-6-11, 1,2-ethanediamine,n,n,n',n'-tetrakis 2-pyridinylmethyl, 1,2-ethanediamine, n,n,n',n'-tetrakis 2-pyridinylmethyl
• InChI Key: CVRXLMUYFMERMJ-UHFFFAOYSA-N
• SMILES: C(CN(CC1=CC=CC=N1)CC1=CC=CC=N1)N(CC1=CC=CC=N1)CC1=CC=CC=N1
• IUPAC Name: (2-{bis[(pyridin-2-yl)methyl]amino}ethyl)bis[(pyridin-2-yl)methyl]amine
• Molecular Weight (g/mol): 424.55
• PubChem CID: 5519
• Formula Weight: 424.54
• Percent Purity: >98%
• Chemical Name or Material: TPEN