TPMPA, Tocris Bioscience™

Description

Selective GABAA-ρ antagonist

A selective, competitive GABAA-ρ antagonist with only minimal effects on GABAA and GABAB receptors (Kb values are 2.1 μM (antagonist), 320 μM (antagonist) and EC50 ∽ 500 μM (weak agonist) respectively). Displays 8-fold selectivity for human recombinant ρ1 receptors over ρ2 receptors.

Specifications

Chemical Identifiers

• CAS: 182485-36-5
• Molecular Formula: C6H12NO2P
• Molecular Weight (g/mol): 161.141
• InChI Key: MFUKVPOVVKKLRQ-UHFFFAOYSA-N
• Synonym: tpmpa, methyl 1,2,3,6-tetrahydropyridin-4-yl phosphinic acid, unii-tr7i0800l2, phosphinic acid, p-methyl-p-1,2,3,6-tetrahydro-4-pyridinyl, 1,2,5,6-tetrahydropyridin-4-yl methylphosphinic acid hydrate, tpmpa mi, methyl 1,2,3,6-tetrahydropyridinium-4-yl phosphinate, biomol-nt_000236, p-methyl-p-1,2,3,6-tetrahydro-4-pyridinyl phosphinic acid, 1,2,5,6-tetrahydropyridin-4-yl methylphosphinsaure
• PubChem CID: 5521
• IUPAC Name: methyl(1,2,3,6-tetrahydropyridin-4-yl)phosphinic acid
• SMILES: CP(=O)(C1=CCNCC1)O

• Quantity: 50 mg
• Formula Weight: 161.14
• Percent Purity: >98%
• Chemical Name or Material: TPMPA