Tranilast, Tocris Bioscience™

Description

Antiallergic; inhibits inflammatory mediator release from mast cells

Tranilast is an antiallergic via inhibition of chemical mediator release from mast cells. Shown to be an effective inhibitor of angiogenesis. Demonstrated to antagonize the effects of angiotensin II on human arteries, possibly by an interaction at the level of the AT1 receptor. Inhibits TRPV2-mediated responses; binds to Aβ40 monomers and increases Aβ40 fibrillation.

Specifications

Chemical Identifiers

• CAS: 53902-12-8
• Molecular Formula: C18H17NO5
• Molecular Weight (g/mol): 327.34
• MDL Number: MFCD00864787
• InChI Key: NZHGWWWHIYHZNX-CSKARUKUSA-N
• Synonym: tranilast, rizaben, trans-tranilast, tranilastum, n-3,4-dimethoxycinnamoyl anthranilic acid, tranilastum inn-latin, tranilast usan:inn:jan, tranpro, unii-hvf50smy6e, rizaben tn
• PubChem CID: 5282230
• ChEBI: CHEBI:77572
• IUPAC Name: 2-[(2E)-3-(3,4-dimethoxyphenyl)prop-2-enamido]benzoic acid
• SMILES: COC1=CC=C(\C=C\C(=O)NC2=CC=CC=C2C(O)=O)C=C1OC

• Quantity: 50 mg
• Formula Weight: 327.34
• Percent Purity: >99%
• Chemical Name or Material: Tranilast