Trichloroacetic acid Solution, MP Biomedicals™

Description

Trichloroacetic acid Solution

• It is used in protein precipitation; has been used to determine protein concentration by quantitative precipitation.
• It is also Used as a decalcifier and fixative in microscopy.
• A protocol for the precipitation of nucleic acids can be found in Molecular Cloning. Rats exposed to chronic sublethal amounts of trichloroacetic acid displayed an increase in serum bilirubin with a decrease in hematological proteins and cholesterols along with significant decreases in red blood corpuscles, mean cell volume, mean corpuscular hemoglobin, hemoglobin and hematocrit.
• In mice the production of liver tumors was associated to Trichloroacetic acid, which is also a known mouse hepatocarinogen.
• On the guinea pig trichloroacetic acid was observed to be a mild alergen on the skin.
• Trichloroacetic acid is an acetic acid analogue commonly used to precipitate proteins, DNA and RNA. In the presence of SDS Trichloroacetic acid will precipitate proteins which can then be quantified by the Lowry method.
• The compound has also found uses as a decalcifier and fixative in microscopy, in protein sequencing, detecting albumin and organic synthesis.

Specifications

• pH: 1.2 (0.1 M aqueous solution)(Literature)
• CAS: 76-03-9
• Melting Point: ∼56°C (Literature)
• Molecular Formula: C2HCl3O2
• MDL Number: MFCD00004177
• UN Number: UN2564
• Beilstein: 970119
• Synonym: trichloroacetic acid, trichloroethanoic acid, aceto-caustin, trichloroacetic acid, acetic acid, trichloro, trichloressigsaeure, konesta, acide trichloracetique, acido tricloroacetico, amchem grass killer
• InChI Key: YNJBWRMUSHSURL-UHFFFAOYSA-N
• SMILES: C(=O)(C(Cl)(Cl)Cl)O
• Concentration: 100% w/v
• IUPAC Name: 2,2,2-trichloroacetic acid
• Molecular Weight (g/mol): 163.4
• PubChem CID: 6421
• ChEBI: CHEBI:30956
• Formula Weight: 163.38
• Density: 1.62 sp. gr.
• Quantity: 100 mL
• Physical Form: Solution
• Chemical Name or Material: Trichloroacetic Acid Solution, 6.1N

Safety and Handling

Product Identifier

• Trichloroacetic Acid, 6.1 N Solution

Signal Word

• Danger

Hazard Category

• Skin corrosion/irritation Category 1 A
• Serious eye damage/eye irritation Category 1
• ACUTE AQUATIC Acute 1
• LONG-TERM AQUATIC HAZARD Chronic 1
• Specific target organ toxicity Category 3

Hazard Statement

• H314-Causes severe skin burns and eye damage.
• H335-May cause respiratory irritation.
• H410-Very toxic to aquatic life with long lasting effects.

Precautionary Statement

• P101-If medical advice is needed, have product container or label at hand.
• P102-Keep out of reach of children.
• P103-Read label before use.
• P260-Do not breathe dust/fume/gas/mist/vapours/spray.
• P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P310-Immediately call a POISON CENTER/doctor/.
• P405-Store locked up.
• P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.

Supplemental information

• MIXTURE LIST-Contains : trichloroacetic acid