Trimethylacetyl chloride, 98+%, Thermo Scientific Chemicals

Product Code	Brand	Quantity
11680212	Thermo Scientific Alfa Aesar A15051.AE	100 mL
11431960	Thermo Scientific Alfa Aesar A15051.AP	500 mL
11441960	Thermo Scientific Alfa Aesar A15051.0F	2500 mL

Description

Trimethylacetyl chloride is used as a precursor in the preparation of tert-butyl peroxypivalate, guttiferon A derivatives, which is potential for the treatment of malaria. It is used as a raw material in the production of synthetic acidamide medicament and phenol ester medicament. In addition to this, it is used for the synthesis of active pharmaceutical ingredients such as aminobenzylpenicilin, cephalexin, cefazolin, dipivefrin and dipivalyl epinephrine. It is also used in heavy polymerization, N-acylating agent for amines, Schiff bases, pyrrolidinones as well as an O-acylating agent for alcohols, lactones and saccharides.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Trimethylacetyl chloride is used as a precursor in the preparation of tert-butyl peroxypivalate, guttiferon A derivatives, which is potential for the treatment of malaria. It is used as a raw material in the production of synthetic acidamide medicament and phenol ester medicament. In addition to this, it is used for the synthesis of active pharmaceutical ingredients such as aminobenzylpenicilin, cephalexin, cefazolin, dipivefrin and dipivalyl epinephrine. It is also used in heavy polymerization, N-acylating agent for amines, Schiff bases, pyrrolidinones as well as an O-acylating agent for alcohols, lactones and saccharides.

Solubility
Miscible with acetonitrile.

Notes
Moisture sensitive. Incompatible withalcohols, oxidizing agents and strong bases.

Chemical Identifiers

• CAS: 3282-30-2
• Molecular Weight (g/mol): 120.58
• InChI Key: JVSFQJZRHXAUGT-UHFFFAOYSA-N
• PubChem CID: 62493
• SMILES: CC(C)(C)C(Cl)=O

• Molecular Formula: C5H9ClO
• MDL Number: MFCD00000709
• Synonym: pivaloyl chloride, trimethylacetyl chloride, propanoyl chloride, 2,2-dimethyl, pivalyl chloride, pivaloylchloride, 2,2-dimethylpropionyl chloride, pivalic acid chloride, pivalolyl chloride, unii-jq82j0o21t, 2,2-dimethylpropionylchloride
• IUPAC Name: 2,2-dimethylpropanoyl chloride

Specifications

• CAS: 3282-30-2
• Density: 0.985
• Flash Point: 8°C (46°F)
• Molecular Formula: C5H9ClO
• MDL Number: MFCD00000709
• Beilstein: 385668
• Synonym: pivaloyl chloride, trimethylacetyl chloride, propanoyl chloride, 2,2-dimethyl, pivalyl chloride, pivaloylchloride, 2,2-dimethylpropionyl chloride, pivalic acid chloride, pivalolyl chloride, unii-jq82j0o21t, 2,2-dimethylpropionylchloride
• InChI Key: JVSFQJZRHXAUGT-UHFFFAOYSA-N
• IUPAC Name: 2,2-dimethylpropanoyl chloride
• PubChem CID: 62493
• Percent Purity: ≥98%

• Melting Point: -57°C
• Boiling Point: 105°C to 106°C
• Odor: Pungent
• Refractive Index: 1.412
• UN Number: UN2438
• Sensitivity: Moisture sensitive
• Solubility Information: Miscible with acetonitrile.
• SMILES: CC(C)(C)C(Cl)=O
• Molecular Weight (g/mol): 120.58
• Formula Weight: 120.58
• Chemical Name or Material: Trimethylacetyl chloride

Safety and Handling

GHS H Statement
H225-H330-H314-H318-H302
Highly flammable liquid and vapour.
Fatal if inhaled.
Causes severe skin burns and eye damage.
Causes serious eye damage.
Harmful if swallowed.

P210-P233-P234-P235-P240-P241-P242-P243-P260-P264b-P270-P271-P280-P284-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P363-P370+P378q-P390-P501c

H225-H290-H302-H314-H330

missing translation for 'dotInformation' : Transport Hazard Class: 6.1; Packing Group: I; Proper Shipping Name: TRIMETHYLACETYL CHLORIDE

missing translation for 'einecsNumber' : 221-921-6

missing translation for 'tsca' : Yes

Recommended Storage : Ambient temperatures

Product Identifier

• Trimethylacetyl chloride

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 2
• Acute toxicity Category 4
• Serious eye damage/eye irritation Category 1
• Flammable liquid Category 2
• Substances and mixtures corrosive to metals Category 1
• Skin corrosion/irritation Category 1 B

Hazard Statement

• H225-Highly flammable liquid and vapour.
• H290-May be corrosive to metals.
• H302-Harmful if swallowed.
• H314-Causes severe skin burns and eye damage.
• H318-Causes serious eye damage.
• H330-Fatal if inhaled.

Precautionary Statement

• P210-Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
• P303+P361+P353-IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/ shower.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P310-Immediately call a POISON CENTER/doctor/.

Supplemental information

• MIXTURE LIST-Contains : Pivaloyl chloride

RUO – Research Use Only