(Trimethylsilyl)diazomethane, 2M in hexanes, Thermo Scientific Chemicals

Product Code	Brand	Quantity
11322739	Thermo Scientific Alfa Aesar H26744.AA	5 mL
11332739	Thermo Scientific Alfa Aesar H26744.AC	25 mL
11342739	Thermo Scientific Alfa Aesar H26744.AE	100 mL

Description

(Trimethylsilyl)diazomethane is used as a methylating agent in organic chemistry. It is utilized in Gas Chromatography- Mass-Spectrometry (GC-MS) for the analysis of various carboxylic compounds. It is involved as a reagent in the Doyle-Kirmse reaction with allyl sulfides and allyl amines. It is considered and used as a less-explosive replacement fordiazomethane. It is also used as a reactant for Unnatural alfa-amino acid derivatives containing gem-bisphosphonates through Michael addition reaction, imidazolo[2,1-b]benzothiazole derivatives and aigialomycin D analogues.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
(Trimethylsilyl)diazomethane is used as a methylating agent in organic chemistry. It is utilized in Gas Chromatography- Mass-Spectrometry (GC-MS) for the analysis of various carboxylic compounds. It is involved as a reagent in the Doyle-Kirmse reaction with allyl sulfides and allyl amines. It is considered and used as a less-explosive replacement fordiazomethane. It is also used as a reactant for Unnatural alfa-amino acid derivatives containing gem-bisphosphonates through Michael addition reaction, imidazolo[2,1-b]benzothiazole derivatives and aigialomycin D analogues.

Solubility
Immiscible with water. Miscible with organic solvents.

Notes
(Trimethylsilyl)diazomethane (TMSD) in alcoholic solvents under acidic or basic conditions can lead to the formation of diazomethane. TMSD is under review by the National Toxicological Program for potential inhalation hazards.Incompatible with oxidizing agents, chlorine, fluorine and perchlorates.

Chemical Identifiers

• CAS: 18107-18-1
• Molecular Weight (g/mol): 114.223
• InChI Key: ONDSBJMLAHVLMI-UHFFFAOYSA-N
• PubChem CID: 167693
• SMILES: C[Si](C)(C)C=[N+]=[N-]

• Molecular Formula: C4H10N2Si
• MDL Number: MFCD00053946
• Synonym: trimethylsilyl diazomethane, trimethylsilyldiazomethane, diazomethyl trimethylsilane, tms-diazomethane, diazomethyl trimethyl silane, tmschn2, silane, diazomethyl trimethyl, unii-qi98hqo8c4, diazomethyl-trimethyl-silane, qi98hqo8c4
• IUPAC Name: diazomethyl(trimethyl)silane

Specifications

• CAS: 18107-18-1
• MDL Number: MFCD00053946
• Beilstein: 1902903
• Synonym: trimethylsilyl diazomethane, trimethylsilyldiazomethane, diazomethyl trimethylsilane, tms-diazomethane, diazomethyl trimethyl silane, tmschn2, silane, diazomethyl trimethyl, unii-qi98hqo8c4, diazomethyl-trimethyl-silane, qi98hqo8c4
• InChI Key: ONDSBJMLAHVLMI-UHFFFAOYSA-N
• IUPAC Name: diazomethyl(trimethyl)silane
• PubChem CID: 167693
• Concentration or Composition (by Analyte or Components): 2M in hexanes
• Density: 0.718

• Molecular Formula: C4H10N2Si
• UN Number: UN3383
• Flash Point: −23°C (−10°F)
• Solubility Information: Immiscible with water. Miscible with organic solvents.
• SMILES: C[Si](C)(C)C=[N+]=[N-]
• Molecular Weight (g/mol): 114.223
• Formula Weight: 114.22
• Sensitivity: Light and moisture sensitive
• Chemical Name or Material: (Trimethylsilyl)diazomethane

Safety and Handling

GHS H Statement
H225-H331-H350-H304-H361-H373-H315-H336
Highly flammable liquid and vapor.
Toxic if inhaled.
May cause cancer.
May be fatal if swallowed and enters airways.
Suspected of damaging fertility or the unborn child.
May cause damage to organs through prolonged or repeated exposure.
Causes skin irritation.
May cause drowsiness or dizziness.

P201-P202-P210-P233-P235-P240-P241-P242-P243-P260-P264b-P271-P280i-P281-P284-P301+P310-P303+P361+P353-P304+P340-P305+P351+P338-P308+P313-P310-P331-P332+P313-P363-P370+P378q-P5

H225-H304-H315-H319-H330-H335-H336-H350-H361f-H373

missing translation for 'dotInformation' : Hazard Class: 3; Packaging Group: II

missing translation for 'tsca' : No

Recommended Storage : Ambient temperatures; Store under Nitrogen

RUO – Research Use Only