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TSLP Monoclonal Antibody (eBio28F12 (28F12)), Functional Grade, eBioscience™, Invitrogen™
Rat Monoclonal Antibody
£296.00 - £7770.00
Specifications
Antigen | TSLP |
---|---|
Clone | eBio28F12 (28F12) |
Concentration | 1 mg/mL |
Applications | Functional Assay, Neutralization |
Classification | Monoclonal |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15268647
|
Invitrogen
16-5491-85 |
500 μg |
£296.00
500µg |
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17141292
|
Invitrogen
16-5491-38 |
5 mg |
£2595.00
5mg |
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17121292
|
Affymetrix eBioscience
16-5491-025 |
25 mg | |||||||
Description
The MAb eBio28F12 reacts with and inhibits the bioactivity of mouse TSLP. Thymic Stromal-Derived Lymphopoetin (TSLP) was first identified in the tissue culture supernatant of a thymic stromal cell line as a growth factor capable of inducing proliferation and differentiation of pre-B cells. It was later found to be closely related to another stromal cytokine, IL-7, with which it shares overlapping functions. Along with its proliferative effects on B cells, TSLP induces dendritic cells to support the differentiation of naive T cells towards the Th2 lineage and may also be involved in the development of CD4^+CD25^+ regulatory T cells. The receptor for TSLP is heterodimeric and shares one subunit, IL-7Ralpha, with IL-7 and other members of the family, while the TSLPR subunit is unique to TSLP. TSLP expression can be induced by a variety of inflammatory cytokines and TLR ligands. Expression is regulated by NF-kappaB and has been detected in epithelial cells, stromal cells, and basophils. Elevated levels of TSLP are associated with asthma and atopic dermatitis, which are both Th2-mediated inflammatory conditions. It is believed that chronic overexpression of TSLP may result in increased sensitivity to allergens, resulting in susceptibility to these conditions.
TSLP is a 159 amino acid four helix-bundle hemopoietic cytokine that signals through a heterodimeric receptor complex consisting of the human TSLP receptor and the IL-7R alpha-chain. It impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes, enhances the maturation of CD11c (+) dendritic cells, naive CD4 (+), and CD8 (+) T cells into proallergic effectors, and primes dendritic cells to produce large amounts of IL-12 after CD40 ligand stimulation. TSLP influences the regulation of the positive selection of regulatory T cells and maintenance of peripheral CD4 (+) T cell homeostasis. It induces allergic inflammation by directly activating mast cells and may be involved in the pathophysiology of inflammatory arthritis. It is expressed in heart, liver and prostate.Specifications
TSLP | |
1 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
PBS with no preservative; pH 7.2 | |
53603 | |
Primary | |
4° C | |
TSLP |
eBio28F12 (28F12) | |
Functional Assay, Neutralization | |
Functional Grade | |
Rat | |
Mouse | |
Q9JIE6 | |
IgG2a κ | |
Affinity chromatography | |
Antibody |
For Research Use Only.