Varenicline tartrate, Tocris Bioscience™

Description

Selective α4β2 partial agonist; orally active

Orally active, subtype-selective partial agonist at α4β2 nicotinic receptors (Ki values are 0.06, 240, 322 and 3540 nM for α4β2, α3β4, α7, α1βγδ receptors respectively). Reduces nicotine-evoked dopamine release in vitro and decreases nicotine self-administration in vivo. Also potently activates PSAM4-5-HT3 and PSAM4-GlyR chimeric ion channels (EC50 values are 4 and 1.6 nM, respectively)

Specifications

Chemical Identifiers

• CAS: 375815-87-5
• Molecular Formula: C17H19N3O6
• Molecular Weight (g/mol): 361.354
• InChI Key: TWYFGYXQSYOKLK-ZBABXEQTSA-N
• Synonym: varenicline tartrate
• PubChem CID: 124080896
• SMILES: C1C2CNCC1C3=CC4=NC=CN=C4C=C23.C(C(C(=O)O)O)(C(=O)O)O

• Quantity: 50 mg
• Formula Weight: 361.37
• Percent Purity: >99%
• Chemical Name or Material: Varenicline tartrate