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VISTA Monoclonal Antibody (MH5A), PerCP-eFluor™ 710, eBioscience™, Invitrogen™
Armenian Hamster Monoclonal Antibody
£96.00 - £277.00
Specifications
Clone | MH5A |
---|---|
Applications | Flow Cytometry |
Classification | Monoclonal |
Conjugate | PerCP-eFluor 710 |
Form | Liquid |
Description
VISTA is a homolog of PD-1 (PD-1H). PD-1H is a 309 aa type I transmembrane protein that belongs to the CD28 superfamily. This cell surface receptor is expressed on nearly all hematopoietic cells except B cells. VISTA negatively regulates T cell responses by suppressing early TCR activation, inhibiting cell proliferation, and suppressing TH1 cytokine production.
VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is a product of the VSIR gene. Although VISTA bears sequence homology to PD-L1 it has a different expression pattern. In both mouse and humans, VISTA is expressed predominantly on hematopoietic cells with the highest densities on myeloid cells, and lower levels on T cells. It is usually absent on B cells. VISTA expressed by antigen presenting cells has been shown to directly suppress proliferation and cytokine production of CD4 and CD8 T cells, making it a target for cancer immunotherapy. The reported ligands of VISTA include CD28H, VSIG-3 and VSIG-8.Specifications
MH5A | |
Monoclonal | |
Liquid | |
RUO | |
Q9D659 | |
IgG | |
Affinity chromatography |
Flow Cytometry | |
PerCP-eFluor 710 | |
Armenian Hamster | |
Mouse | |
74048 | |
Primary | |
Antibody |
For Research Use Only.