VU 0357017 hydrochloride, Tocris Bioscience™

Description

Positive allosteric modulator of M1 receptors

Positive allosteric modulator of muscarinic M1 receptors (EC50 = 198 nM). Displays no activity at M2-M5 at concentrations up to 30 μM. Potentiates NMDA receptor currents in hippocampal neurons; activity reverses cognitive decifits in a rodent model of hippocampal-dependent memory. CNS penetrant.

Specifications

Chemical Identifiers

• CAS: 1135242-13-5
• Molecular Formula: C18H28ClN3O3
• Molecular Weight (g/mol): 369.89
• InChI Key: XKJQVUIXSBOCPP-UHFFFAOYSA-N
• Synonym: vu 0357017 hydrochloride, vu0357017 hydrochloride, ethyl 4-2-2-methylbenzamido ethylamino piperidine-1-carboxylate hydrochloride, 4-2-2-methylbenzoyl amino ethyl amino-1-piperidinecarboxylic acid ethyl ester hydrochloride, ml071 hydrochloride, vu0357017 monohydrochloride, cid, hcl, vu0357017 monohydrochloride hplc
• PubChem CID: 25010775
• IUPAC Name: ethyl 4-[2-[(2-methylbenzoyl)amino]ethylamino]piperidine-1-carboxylate;hydrochloride
• SMILES: CCOC(=O)N1CCC(CC1)NCCNC(=O)C2=CC=CC=C2C.Cl

• Quantity: 10 mg
• Formula Weight: 369.89
• Percent Purity: >98%
• Chemical Name or Material: VU 0357017 hydrochloride