VX 745, Tocris Bioscience™

Description

Potent and selective p38α inhibitor

VX 745 is a highly potent and selective p38α/MAPK14 inhibitor, also inhibits p38β (IC50 values are 10 nM and 220 nM respectively). VX 745 blocks TNFα production in LPS-stimulated HWB in vitro (IC50 = 51-180 nM). Also reduces phosphorylation of p38MAPKα and the downstream target Hsp27, leading to vasodilation, reduces IL-1β levels and amyloid plaques in cortex and hippocampus and lowers CSF tau levels in vivo.

Specifications

Chemical Identifiers

• CAS: 209410-46-8
• Molecular Formula: C19H9Cl2F2N3OS
• Molecular Weight (g/mol): 436.26
• MDL Number: MFCD09834070
• InChI Key: VEPKQEUBKLEPRA-UHFFFAOYSA-N
• Synonym: 5-2,6-dichlorophenyl-2-2,4-difluorophenyl thio-6h-pyrimido 1,6-b pyridazin-6-one, neflamapimod, unii-tyl52qm320, 5-2,6-dichlorophenyl-2-2,4-difluorophenylthio-6h-pyrimido 1,6-b pyridazin-6-one, neflamapimod usan, 5-2,6-dichlorophenyl-2-2,4-difluorophenyl sulfanylpyrimido 1,6-b pyridazin-6-one, 5-2,6-dichlorophenyl-2-2,4-difluorophenyl sulfanylpyridazino 6,1-f pyrimidin-6-one, 5-2,6-dichlorophenyl-2-2,4-difluorophenyl sulfanyl-6h-pyrimido 1,6-b pyridazin-6-one
• PubChem CID: 3038525
• IUPAC Name: 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-b]pyridazin-6-one
• SMILES: FC1=CC=C(SC2=NN3C=NC(=O)C(=C3C=C2)C2=C(Cl)C=CC=C2Cl)C(F)=C1

• Quantity: 50 mg
• Formula Weight: 436.26
• Percent Purity: >98%
• Chemical Name or Material: VX 745