Thermo Scientific Chemicals Wortmannin, Penicillium funiculosum, 99+%

Description

Inhibitor of phosphatidylinositol 3-kinase

Wortmannin is used as inhibitor of phosphatidylinositol 3-kinase, used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation. It inhibits fMLP induced PIP3 and superoxide anion production in guinea pig neutrophils. It blocks insulin metabolic effects in rat adipocytes without affecting the insulin receptor tyrosine kinase activity.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Specifications

Chemical Identifiers

• CAS: 19545-26-7
• Molecular Formula: C₂₃H₂₄O₈, C23H24O8
• Synonym: KY 12420

• Quantity: 50 mg
• Description: White to Off-white
• Content And Storage: -30°C to -10°C
• For Use With (Application): Inhibitor of phosphatidylinositol 3-kinase
• Formula Weight: 428.44g/mol
• Sensitivity: Light Sensitive
• Product Type: Signal Transduction Reagent
• Form: Powder
• Beilstein: 67676
• InChI Key: QDLHCMPXEPAAMD-QAIWCSMKSA-N
• SMILES: COC[C@H]1OC(=O)C2=COC3=C2[C@@]1(C)C1=C([C@@H]2CCC(=O)[C@@]2(C)C[C@H]1OC(C)=O)C3=O
• IUPAC Name: (1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.0²,¹⁰.0⁵,⁹.0¹⁵,¹⁹]nonadeca-2(10),12(19),14-trien-3-yl acetate
• Molecular Weight (g/mol): 428.44
• Assay: ≥99%

RUO – Research Use Only