Thermo Scientific Chemicals Wortmannin, Penicillium funiculosum, 99+%

Product Code	Brand	Quantity
15406129	Thermo Scientific Chemicals J63983.MB	25 mg
15416129	Thermo Scientific Chemicals J63983.MF	50 mg
15496119	Thermo Scientific Chemicals J63983.MA	10 mg

Description

Wortmannin is used as inhibitor of phosphatidylinositol 3-kinase, used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation. It inhibits fMLP induced PIP3 and superoxide anion production in guinea pig neutrophils. It blocks insulin metabolic effects in rat adipocytes without affecting the insulin receptor tyrosine kinase activity.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Chemical Identifiers

• CAS: 19545-26-7
• Molecular Formula: C₂₃H₂₄O₈, C23H24O8
• Synonym: KY 12420

Specifications

• Description: White to Off-white
• For Use With (Application): Inhibitor of phosphatidylinositol 3-kinase
• Molecular Formula: C₂₃H₂₄O₈, C23H24O8
• Synonym: KY 12420
• Product Type: Signal Transduction Reagent
• Beilstein: 67676
• SMILES: COC[C@H]1OC(=O)C2=COC3=C2[C@@]1(C)C1=C([C@@H]2CCC(=O)[C@@]2(C)C[C@H]1OC(C)=O)C3=O
• Molecular Weight (g/mol): 428.44

• Content And Storage: -30°C to -10°C
• CAS: 19545-26-7
• Formula Weight: 428.44g/mol
• Sensitivity: Light Sensitive
• Form: Powder
• InChI Key: QDLHCMPXEPAAMD-QAIWCSMKSA-N
• IUPAC Name: (1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.0²,¹⁰.0⁵,⁹.0¹⁵,¹⁹]nonadeca-2(10),12(19),14-trien-3-yl acetate
• Assay: ≥99%

Safety and Handling

Recommended Storage : Store at -20°C

RUO – Research Use Only