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WWTR1 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA146190
This item is not returnable.
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Description
Suggested positive control: 293 whole cell lysate, antigen standard for WWTR1 (transient overexpression lysate), HEK 293 lysate and kidney tissue lysate, human kidney protein.
WW domain-containing transcription regulator protein 1 (WWTR1) is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor supression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1. In turn, MOB1 phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. WWTR1 regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. WWTR1 also regulates embryonic stem-cell self-renewal and promotes cell proliferation and epithelial-mesenchymal transition.Specifications
WWTR1 | |
Polyclonal | |
Unconjugated | |
WWTR1 | |
2310058J06Rik; 2610021I22Rik; C78399; DKFZp586I1419; FLJ27004; FLJ45718; Tafazzin; TAZ; transcriptional coactivator with PDZ binding motif; transcriptional co-activator with PDZ-binding motif; transcriptional coactivator with PDZ-binding motif; transcriptional co-activator with PDZ-binding motif (TA)Z; transcriptional co-activator with PDZ-binding motif (TAZ); WW domain containing transcription regulator 1; WW domain-containing transcription regulator protein 1; Wwtr1 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
25937, 295062, 97064 | |
-20°C or -80°C if preferred | |
Liquid |
ChIP Assay, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Proximity Ligation Assay, Western Blot | |
1 mg/mL | |
PBS with 0.02% sodium azide | |
Q9EPK5, Q9GZV5 | |
WWTR1 | |
Human TAZ protein. | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |