XPA Monoclonal Antibody (12F5), Invitrogen™

Mouse Monoclonal Antibody

Brand:  Invitrogen MA513835

Product Code. 11314933

Description

MA5-13835 targets XPA in IHC (P) and WB applications and shows reactivity with Human samples. The MA5-13835 immunogen is recombinant human XPA protein.

The XPA (xeroderma pigmentosumgroup A) protein specifically recognizes the UV-orchemically damaged DNA lesions, and triggers thenucleotide excision repair process. XPA binds to thereplication protein A (RPA) or the excision repaircross complementing 1 protein (ERCC 1). In the absence of nucleotide excision repair persisting (unrepaired) DNA lesions (adducts) may lead to the accumulation of gene mutations and μgtimately to cancer. Xeroderma pigmentosum patients have a >2000 fold increased risk to develop skin cancer atsun-exposed areas.

Specifications

• Antigen: XPA
• Classification: Monoclonal
• Concentration: 0.2 mg/mL
• Formulation: PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
• Gene Accession No.: P23025
• Gene Symbols: XPA
• Immunogen: Recombinant human XPA protein
• Quantity: 500 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a κ

• Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
• Clone: 12F5
• Conjugate: Unconjugated
• Gene: XPA
• Gene Alias: AI573865; DNA repair protein complementing XP-A cells; DNA repair protein complementing XP-A cells homolog; excision repair-controlling; mutant xeroderma pigmentosum complementation group A; xeroderma pigmentosum group A-complementing protein; Xeroderma pigmentosum group A-complementing protein homolog; xeroderma pigmentosum, complementation group A; XP1; XPA; XPA, DNA damage recognition and repair factor; Xpac
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 7507
• Content And Storage: 4° C
• Form: Liquid