Tocris™ 1A-116

Rac1 inhibitor; blocks Rac1-P-Rex1 interaction

Brand:  Tocris™ 6701/10

Product Code. 18054522

Description

1A-116 is a Rac1 inhibitor. Reduces intracellular Rac1-GTP levels and blocks Rac1-P-Rex1 interaction in vitro. Exhibits no effect on GTPase activity of closely related Cdc42. Displays antiproliferative, anti-invasive and pro-apoptotic activity in several cancer cell lines. Exhibits antimetastatic activity in vivo. Also restores antiproliferative effects of Tamoxifen (Cat. No. 6342) in resistant breast cancer cell.

Specifications

• Chemical Name or Material: N-(3,5-Dimethylphenyl)-N-[2-(trifluoromethyl)phenyl]guanidine
• Quantity: 10 mg
• Formula Weight: 307.31
• Purity: 98%

• CAS: 1430208-73-3
• Molecular Formula: C₁₆H₁₆F₃N₃
• Product Type: Inhibitor