Tocris Bioscience™ AC 710

Potent and selective PDGFR family inhibitor

Brand:  Tocris Bioscience™ 5013/10

Product Code. 18720278

Description

AC 710 is a potent PDGFR family inhibitor (IC50 values are 1.2, 2, 7.7 and 10.5 nM for KIT, FLT3, PDGFRβ and CSF1R respectively; Kd = 1.3 nM for PDGFRα). Exhibits >30-fold selectivity over a panel of other kinases and exhibits no activity against cytochrome P450. Causes tumor regression of leukemia cell xenografts in mice. Also reduces joint swelling and inflammation in a mouse model of collagen-induced arthritis. Orally active.

Specifications

• Purity: >99%
• Molecular Weight (g/mol): 562.7
• Quantity: 10 mg

• Description: AC 710
• Product Type: AC 710

For Research Use Only