Thermo Scientific Chemicals Bafilomycin A1, 95%

Product Code. 10295441

Brand: Thermo Scientific Chemicals 328120001

Description

Bafilomycin A1, CAS # 88899-55-2, is an inhibitor of vacuolar ATPases from Streptomyces griseus that has antibacterial, antifungal, and antineoplastic activity.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Bafilomycin A1 is a specific potent inhibitor of vacuolar ATPases
• It is a macrolide antibiotic, and shows fungicide activity

Application

• Bafilomycin A1 has antibacterial, antifungal, and antineoplastic activity
• It can be immunosuppressive
• It can prevent maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes
• It is a potent and selective inhibitor of vacuolar-type H+ ATPase (V-ATPase)

Specifications

• Type: Bafilomycin A1
• Physical Form: Powder/Solid
• CAS: 88899-55-2
• Color: White
• Quantity: 0.1 mg
• Assay Percent Range: 95%
• Molecular Formula: C35H58O9
• MDL Number: MFCD06795130
• Solubility Information: Solubility in water: practically insoluble. Other solubilities: soluble in methanol, ethanol, dmso
• InChI Key: XDHNQDDQEHDUTM-XRCNURIOSA-N
• SMILES: CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)O)O)O)OC)C
• IUPAC Name: (3Z,5E,7S,8R,9R,11Z,15R,16S)-16-[(2R,3S,4R)-4-[(2S,4S,5R,6S)-2,4-dihydroxy-5-methyl-6-propan-2-yloxan-2-yl]-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one
• Molecular Weight (g/mol): 622.84
• PubChem CID: 133268469
• Formula Weight: 622.8
• Percent Purity: 95%
• Chemical Name or Material: Bafilomycin A1, 95%

Safety and Handling

Product Identifier

• Bafilomycin A1

Signal Word

• Warning

Hazard Category

• Serious eye damage/eye irritation Category 2
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H319-Causes serious eye irritation.
• H335-May cause respiratory irritation.
• H315-Causes skin irritation.

Precautionary Statement

• P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P302+P352-IF ON SKIN: Wash with plenty of water/.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

SDS

RUO – Research Use Only