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Tocris Bioscience™ BIRB 796

High affinity and selective p38 kinase inhibitor

Brand:  Tocris Bioscience™ 5989/50

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Product Code. 18737196

  • £420.00 / 50mg

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Description

Description

BIRB 796 is a high affinity and selective p38 kinase inhibitor (Kd = 50-100 pM). Exhibits no significant inhibition on a panel of related kinases. Inhibits LPS-induced TNFα production in human PBMCs and whole blood (IC50 values are 21 and 960 nM, respectively). Also inhibits JNK2α2 and c-Raf-1 (IC50 values are 98 nM and 1.4 μM, respectively). Cell permeable.
Specifications

Specifications

N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N′-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea
Doramapimod
p38 Inhibitors
527.66
285983-48-4
50 mg
C31H37N5O3
0.98
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