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Tocris Bioscience™ BIRB 796
High affinity and selective p38 kinase inhibitor
£124.00 - £420.00
Specifications
| Chemical Name or Material | N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N′-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea |
|---|---|
| CAS | 285983-48-4 |
| Synonym | Doramapimod |
| Target | p38 Inhibitors |
| Molecular Formula | C31H37N5O3 |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
18757996
|
Tocris Bioscience™
5989/10 |
10 mg |
£124.00
10mg |
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|
18737196
|
Tocris Bioscience™
5989/50 |
50 mg |
£420.00
50mg |
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Description
High affinity and selective p38 kinase inhibitor (Kd = 50-100 pM). Exhibits no significant inhibition on a panel of related kinases. Inhibits LPS-induced TNFα production in human PBMCs and whole blood (IC50 values are 21 and 960 nM, respectively). Also inhibits JNK2α2 and c-Raf-1 (IC50 values are 98 nM and 1.4 μM, respectively). Cell permeable.Specifications
| N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N′-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea | |
| Doramapimod | |
| C31H37N5O3 | |
| 0.98 |
| 285983-48-4 | |
| p38 Inhibitors | |
| 527.66 |
Safety and Handling
Recommended Storage : Store at -20°C