Tocris Bioscience™ BIRB 796

High affinity and selective p38 kinase inhibitor

Brand:  Tocris Bioscience™ 5989/10

Product Code. 18757996

Description

BIRB 796 is a high affinity and selective p38 kinase inhibitor (Kd = 50-100 pM). Exhibits no significant inhibition on a panel of related kinases. Inhibits LPS-induced TNFα production in human PBMCs and whole blood (IC50 values are 21 and 960 nM, respectively). Also inhibits JNK2α2 and c-Raf-1 (IC50 values are 98 nM and 1.4 μM, respectively). Cell permeable.

Specifications

• Chemical Name or Material: N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N′-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea
• Synonym: Doramapimod
• Target: p38 Inhibitors
• Formula Weight: 527.66

• CAS: 285983-48-4
• Quantity: 10 mg
• Molecular Formula: C₃₁H₃₇N₅O₃
• Purity: 0.98