Thermo Scientific Chemicals Cefotaxime sodium salt, 95%

Product Code	Brand	Quantity	Packaging
15219946	Thermo Scientific Chemicals 454950010	1 g	Glass Bottle
15229946	Thermo Scientific Chemicals 454950050	5 g	Glass Bottle
15269896	Thermo Scientific Chemicals 454950250	25 g	Glass Bottle

Description

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Information

• The cefotaxime sodium salt is a - lactamase considered a third-generation cephalosporin with antibiotic and bactericidal activities
• This compound exerts its biological activity by binding to penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall leading to their inactivation. The inactivation of these proteins affects the cross-linking of peptidoglycan chains required for bacterial cell wall strength and rigidity, resulting in the weakening of cell walls and cell lysis.

Applications

• It is an efficient antibacterial compound that acts against gram-negative bacteria, without activity against gram-positive bacteria such as pseudomonas and penicillin-resistant strains of streptococcus pneumonia
• It has been used for plant cell culture and human cell lines in vitro
• Cefotaxime sodium salt has been used in antibiotic susceptibility testing (AST) methods
• Cefotaxime sodium salt is also used to remove bacteria from Ostreococcus tauri cultures

Chemical Identifiers

• CAS: 64485-93-4
• Molecular Weight (g/mol): 477.44
• InChI Key: AZZMGZXNTDTSME-JUZDKLSSSA-M
• SMILES: [Na+].CO\N=C(/C(=O)N[C@H]1[C@H]2SCC(COC(C)=O)=C(N2C1=O)C([O-])=O)C1=CSC(N)=N1

• Molecular Formula: C16H16N5NaO7S2
• MDL Number: MFCD00079073
• PubChem CID: 88631411

Specifications

• Type: Cefotaxime Sodium Salt
• Melting Point: 201.0°C to 210.0°C
• Molecular Formula: C16H16N5NaO7S2
• Solubility Information: Solubility in water: soluble.
• SMILES: [Na+].CO\N=C(/C(=O)N[C@H]1[C@H]2SCC(COC(C)=O)=C(N2C1=O)C([O-])=O)C1=CSC(N)=N1
• Molecular Weight (g/mol): 477.44
• Formula Weight: 477.44
• Chemical Name or Material: Cefotaxime sodium salt

• CAS: 64485-93-4
• Assay Percent Range: 95%
• MDL Number: MFCD00079073
• InChI Key: AZZMGZXNTDTSME-JUZDKLSSSA-M
• IUPAC Name: sodium (6R,7R)-3-[(acetyloxy)methyl]-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• PubChem CID: 88631411
• Percent Purity: 95%

Safety and Handling

Product Identifier

• Cefotaxime sodium salt

Signal Word

• Danger

Hazard Category

• Serious eye damage/eye irritation Category 2
• Respiratory sensitiser Category 1
• Skin corrosion/irritation Category 2
• Skin sensitiser Category 1
• Specific target organ toxicity Category 3

Hazard Statement

• H317-May cause an allergic skin reaction.
• H334-May cause allergy or asthma symptoms or breathing difficulties if inhaled.
• H319-Causes serious eye irritation.
• H335-May cause respiratory irritation.
• H315-Causes skin irritation.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P302+P352-IF ON SKIN: Wash with plenty of water/.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P312-Call a POISON CENTER/doctor/if you feel unwell.

RUO – Research Use Only