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Gibco™ CTS™ HiFi Cas9 Protein

Gibco CTS HiFi Cas9 Protein is our GMP-manufactured high-fidelity CRISPR-Cas9 protein, engineered to deliver reduced off-target effects while maintaining high on-target activity.

Brand:  Gibco™ A54223

Additional Details : Weight : 0.01200kg

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Product Code. 17954721

  • £12563.00 / 2.50mg
Estimated Shipment: 09-08-2024
to see stock.

Description

Description

Gibco CTS HiFi Cas9 Protein is our GMP-manufactured high-fidelity CRISPR-Cas9 protein, engineered to deliver reduced off-target effects while maintaining high on-target activity. This protein is designed and manufactured in compliance with the principles of GMP and to meet requirements of the standards for Ancillary Materials for Cell, Gene, and Tissue-Based Products. It is provided in a high-concentration and large-scale format for process development and clinical research applications.

Features of CTS HiFi Cas9 Protein include:
Exceptional off-target profile—over 70% reduction in off-target effects in primary immune cells, compared to CTS TrueCut Cas9 (wild type) at tested loci
Maintain on-target activity—achieve comparable on-target activity to CTS TrueCut Cas9 (wild type) in primary immune cells at tested loci
Stringent manufacturing process—manufactured to meet the standards for Ancillary Materials for Cell, Gene, and Tissue-Based Products including USP , Ph.Eur. 5.2.12, and ISO 20399 following the principles of 21 CFR Part 820 in an FDA-registered manufacturing site
Extensive safety testing—includes sterility, endotoxin, mycoplasma, residual nucleic acid, and protein testing
Traceability documentation—COA, COO, Drug Master files, and Regulatory Support files* are available

CTS HiFi Cas9 Protein is a Streptococcus pyogenes high-fidelity Cas9 protein, produced by recombinant DNA technology in E. coli for genome editing with CRISPR technology. Cas9 protein forms a very stable RNP complex with the guide RNA (gRNA) component of the CRISPR-Cas9 system. Incorporation of NLS aids delivery to the nucleus, increasing the editing efficiency and on-target cleavage.

If you would like to evaluate our HiFi Cas9 protein or conduct small-scale research experiments, we recommend using our research-grade TrueCut HiFi Cas9 Protein (Cat. No. A50576).


*Country-specific Regulatory Support File process will be initiated upon request and will require additional documentation time.

Specifications

Specifications

10 mg/mL
Cas9 Protein
Dry Ice
Liquid
ISO 13485
2.5 mg
Store at –20°C.
E. coli
Genome Editing
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