Thermo Scientific Chemicals D-Cycloserine, 98%

Product Code	Brand	Quantity	Packaging
10683062	Thermo Scientific Chemicals 228480010	1 g	Glass bottle
10450501	Thermo Scientific Chemicals 228480050	5 g	Glass bottle
10646734	Thermo Scientific Chemicals 228480250	25 g	Glass bottle

Description

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

• D-Cycloserine was originally isolated from Streptomyces orchidaceus and is currently formulated as an oral antibiotic
• It is incompatible with strong oxidizing agents but stable under basic conditions, with the greatest stability at pH = 11.5
• D-Cycloserine inhibits L-alanine racemase and D-alanine:D-alanine ligase, 2 enzymes responsible for bacterial cell wall synthesis
• When ingested, D-Cycloserine traverses the blood-brain barrier, potentially causing neurological side effects such as, dizziness, nausea, depression, tremors, etc.

Applications

• D-Cycloserine is a broad-spectrum antibiotic used as a second line agent for treatment of drug-resistant tuberculosis, always in combination with other antituberculosis agents
• It is an excitatory amino acid and partial agonist of the NMDA receptor in the central nervous system (CNS), thus playing a potential role in the amelioration of neuropathic pain
• D-Cycloserine has also been shown to play a role in neural connectivity, and is therefore used to study treatment applications in anxiety disorders and schizophrenia

Chemical Identifiers

• CAS: 68-41-7
• Molecular Weight (g/mol): 102.09
• InChI Key: DYDCUQKUCUHJBH-UWTATZPHSA-N
• PubChem CID: 6234
• IUPAC Name: (4R)-4-amino-1,2-oxazolidin-3-one

• Molecular Formula: C₃H₆N₂O₂
• MDL Number: MFCD00005353
• Synonym: d-cycloserine, cycloserine, seromycin, orientomycin, oxamycin, cyclorin, cyclo-d-serine, cicloserina, farmiserina, miroseryn
• ChEBI: CHEBI:40009
• SMILES: C1C(C(=O)NO1)N

Specifications

• CAS: 68-41-7
• Melting Point: 147.0°C
• pH: 5.5 to 6.5 (10% soln.)
• Loss on Drying: 1% max. (60°C, 3 hrs) (vacuum)
• Assay Percent Range: 98%
• MDL Number: MFCD00005353
• Specific Rotation: + 111.00
• Solubility Information: Solubility in water: soluble. Other solubilities: slightly soluble in methanol and propylene glycol
• SMILES: C1C(C(=O)NO1)N
• Molecular Weight (g/mol): 102.09
• ChEBI: CHEBI:40009
• Percent Purity: 98%
• Chemical Name or Material: D-Cycloserine, 98+%

• Absorbance: Condensation products 0.8 max. (c=0.04, 0.1N NaOH) at 285nm
• Color: White to Yellow
• Ignition Residue: 0.5% max. ()
• Infrared Spectrum: Authentic
• Molecular Formula: C₃H₆N₂O₂
• Merck Index: 15,2749
• Synonym: d-cycloserine, cycloserine, seromycin, orientomycin, oxamycin, cyclorin, cyclo-d-serine, cicloserina, farmiserina, miroseryn
• InChI Key: DYDCUQKUCUHJBH-UWTATZPHSA-N
• IUPAC Name: (4R)-4-amino-1,2-oxazolidin-3-one
• PubChem CID: 6234
• Formula Weight: 102.09
• Physical Form: Crystalline Powder or Crystals

Safety and Handling

missing translation for 'einecsNumber' : 200-688-4

missing translation for 'rtecsNumber' : NY2975000

Product Identifier

• D-Cycloserine

RUO – Research Use Only