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DICER1 Rabbit anti-Human, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Brand: Proteintech 20567-1-AP-150UL
This item is not returnable.
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Description
The antibody is specific to DICER1. The calculated molecular weight of DICER1 is 219 kDa, but modified DICER1 is about 220-250 kDa. DICER1 has isoforms with molecular weight 219 kDa and 93 kDa.
Sphingosine Kinase (SphK) catalyzes the phosphorylation of the lipid sphingosine, creating the bioactive lipid sphingosine-1-phosphate (S1P). S1P subsequently signals through cell surface G protein-coupled receptors, as well as intracellularly, to modulate cell proliferation, survival, motility and differentiation. SphK is an important signaling enzyme which is activated by diverse agents, including growth factors that signal through receptor tyrosine kinases, agents activating G protein-coupled receptors, and immunoglobulin receptors. Two SphK isotypes, SphK-1 and SphK-2, have been cloned, and both isotypes are ubiquitously expressed. SphK-1 has been shown to mediate cell growth, prevention of apoptosis, and cellular transformation, and is upregulated in a variety of human tumors. In contrast, SphK-2 increases apoptosis, and may be responsible for phosphorylating and activating the immunosuppressive drug FTY720.Specifications
| DICER1 | |
| Polyclonal | |
| Unconjugated | |
| DICER1 | |
| DCR1, Dicer, dicer 1, ribonuclease type III, DICER1, Endoribonuclease Dicer, Helicase MOI, Helicase with RNase motif, HERNA, KIAA0928 | |
| Rabbit | |
| Antigen Affinity Chromatography | |
| RUO | |
| 23405 | |
| -20°C | |
| Liquid |
| Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
| 0.57 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
| Q9UPY3 | |
| DICER1 | |
| Peptide | |
| 150 μL | |
| Primary | |
| Human | |
| Antibody | |
| IgG |