Thermo Scientific™ EZ-Link™ Amine-PEG3-Biotin

Biotinylate proteins or surfaces using EDC or other amine-reactive crosslinkers with a mid-length (22.9A) biotinylation reagent containing a 3-unit polyethylene glycol spacer.

Brand:  Thermo Scientific™ 21347

Product Code. 11881215

Description

Thermo Scientific™ EZ-Link Amine-PEG³-Biotin is a biotinylation reagent that contains a 3-unit polyethylene glycol (PEG) spacer arm and a terminal primary amine for conjugation and protein labeling with EDC or other crosslinkers.

Amine-PEG2-Biotin is a water-soluble biotin compound containing polyethylene glycol (PEG) spacer arm and a terminal primary amine. The hydrophilic PEG spacer arm imparts water solubility that is transferred to molecules that are conjugated to the biotin compound. The PEG spacer arm also gives this reagent a long and flexible connection to minimize steric hindrance involved with binding to avidin molecules. The amine group of this amine-PEG-biotin compound can be reacted with the crosslinker EDC to form conjugates with carboxylates and 5' phosphates.

Highlights:

• Use the EDC crosslinker to couple this analog to carboxyl (-COOH) groups or 5' phosphate groups
• Water-soluble, polyethylene glycol (PEG) spacer arm
• Longer chain length for reduction of steric hindrance
• PEG spacer arm transfers hydrophilicity to final conjugate

Specifications

• Product Type: Amine-PEG3-Biotin
• Content And Storage: Store at 4°C.
• Cell Permeability: Cell-Impermeant
• Reactive Moiety: Amine
• Label or Dye: Biotin
• Label Type: Biotin & Analogs

• Quantity: 50 mg
• Product Line: EZ-Link™
• Chemical Reactivity: Carboxylic Acid, Ketone, Aldehyde
• Solubility: Water
• Spacer: Mid-length, Pegylated

Safety and Handling

Product Identifier

• EZ-Link Amine-PEG3-Biotin

Signal Word

• Warning

Hazard Category

• Serious eye damage/eye irritation Category 2
• Skin corrosion/irritation Category 2
• Specific target organ toxicity Category 3

Hazard Statement

• H315-Causes skin irritation.
• H319-Causes serious eye irritation.
• H335-May cause respiratory irritation.

Precautionary Statement

• P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
• P264-Wash hands thoroughly after handling.
• P271-Use only outdoors or in a well-ventilated area.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P332+P313-If skin irritation occurs: Get medical advice/attention.
• P337+P313-If eye irritation persists: Get medical advice/attention.
• P403+P233-Store in a well-ventilated place. Keep container tightly closed.
• P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.

Supplemental information

• MIXTURE LIST-Contains : EZ-Link Amine-PEG3-Biotin

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For Research Use Only. Not for use in diagnostic procedures.