Tocris Bioscience™ FTY 720

Potent S1P receptor agonist; also immunosuppressant

Brand:  Tocris Bioscience™ 6176/50

Product Code. 18761508

Description

FTY 720 is an S1P receptor agonist; undergoes phosphorylation by sphingosine kinase 2, which then binds S1P1,3,4 and 5 receptors (EC50 values are 0.3 - 0.6 nM for S1P1, 4 and 5 and ∼3 nM for S1P3). Immunosuppressant; sequesters lymphocytes in lymph nodes, reducing autoimmune response. Suppresses the development of EAE (an in vivo model of MS). Orally bioavailable and blood-brain barrier permeable.

Specifications

• Product Type: Agonist
• CAS: 162359-56-0
• Formula Weight: 343.93g/mol
• Content And Storage: Store at -20°C
• Quantity: 50 mg

• Target Proteins: Sphingosine-1-phosphate Receptor
• Molecular Formula: C₁₉H₃₃NO₂.HCl
• Synonym: Fingolimod, Gilenya
• For Use With (Application): Sphingosine-1-phosphate Receptor Agonists

For Research Use Only