Thermo Scientific™ GeneBLAzer™ ENDRB-NFAT-bla HEK 293T Cells

GeneBLAzer™ EDNRB-NFAT-bla HEK293T cells contain the human Endothelin Type B Recpetor (EDNRB) stably integrated into the CellSensor™ NFAT-bla HEK293T cell line.

Brand:  Thermo Scientific™ K1727

Product Code. 10542764

Description

GeneBLAzer™ EDNRB-NFAT-bla HEK293T cells contain the human Endothelin Type B Recpetor (EDNRB) stably integrated into the CellSensor™ NFAT-bla HEK293T cell line. CellSensor™ NFAT-bla HEK293T cells (Cat. No. K1538) contain a beta-lactamase reporter gene under control of the Nuclear Factor of Activated T-cells (NFAT) response element.

The GeneBLAzer™ EDNRB-NFAT-bla HEK293T cells are functionally validated for Z' and EC₅₀ concentrations of ET-1. In addition, GeneBLAzer™ EDNRB-NFAT-bla HEK293T cells have been tested for assay performance under variable conditions. These data are found in the Validation & Assay Performance Summary.

The ENDRB receptor mediates signaling of endothelin proteins that regulate several critical biological processes, including the development and function of blood vessels, the production of certain hormones, and the stimulation of cell growth and division. Defects in EDNRB mediated signaling have been implicated in a wide range of diseases, including cancer, hypertension and cardiovascular disorders.

For Academic pricing please login or contact us at discoverysciences@invitrogen.com.

Specifications

• Accession Number: NM_000115.1
• Cell State: Dividing Cells
• Detection Method: Fluorescence
• Gene Symbol: EDNRB
• Population Status: Single Cell Clone Origin
• Quantity: 2 x 10⁶ Cells
• Target Entry: EDNRB
• Cell Line: 293T (HEK)
• Druggable Target: GPCR

• Assay Entry: Cell-based beta lactamase reporter gene
• Content And Storage: LiveBLAzer™-FRET B/G Loading Kit, Solution D and other materials are required separately; please refer to the protocol.
  
  Includes:
  • GeneBLAzer™ EDNRB-NFAT-bla HEK293T cells
  • GeneBLAzer™ EDNRB-NFAT-bla HEK293T Assay Protocol
  • Certificate of Analysis
  
  The GeneBLAzer™ GeneBLAzer™ EDNRB-NFAT-bla HEK293T cells are shipped on dry ice and should be stored in liquid nitrogen immediately upon receipt.
• For Use With (Application): FRET
• Includes: EDNRB-NFAT-bla HEK293T cells, EDNRB-NFAT-bla HEK293T Assay Protocol, Certificate of Analysis
• Product Line: GeneBLAzer™
• Reporter Gene: BLA (Beta-Lactamase)
• Type: Cell Line
• System Type: GeneBLAzer™

For Research Use Only. Not for use in diagnostic procedures.