Epredia™ Glypican-3 (Clone 1G12), Mouse Monoclonal Antibody

Obtain accurate, reproducible results in immunohistochemistry experiments with Epredia™ Glypican-3 (Clone 1G12), Mouse Monoclonal Antibody.

Brand:  Epredia™ MS-1939-R7

Product Code. 15240655

Description

Glypican-3 (GPC3), is a member of the glypican family of heparan sulfate proteoglycans.  GPC3 has an important role in cell growth and differentiation. GPC3 expression has been observed in embryonic tissue including fetal liver while benign and healthy liver specimens are negative. Literature suggests that GPC3 is overexperssed in hepatocellular carcinoma (HCC) while it appears to be down-regulated in several other malignancies such as mesothelioma, ovarian carcinoma, breast carcinoma and intrahepatic Cholangiocarcinomas.  Studies also suggest a potential link between GPC3 expression and poor prognosis in HCC3.  In addition, Avidel-Ronen et al suggests that Glypican-3 is a potential marker for early detection of squamous cell carcinoma of the lung².  

Host Species: Mouse
Clone: 1G12
Isotype: IgG1
Species Reactivity: Human. Others not tested
Epitope: Not determined
Immunogen: The last 70 amino acids of the core protein
Molecular Weight: ∼60kDa
Positive Control: Hepatocellular carcinoma or placenta
Cellular Localization: Cytoplasmic
Recommended for: Immunohistochemistry

Specifications

• Applications: Immunohistochemistry
• Classification: Monoclonal
• Conjugate: Unconjugated
• Immunogen: The last 70 amino acids of the core protein
• Positive Control: Hepatocellular carcinoma or placenta
• Quantity: 7 mL
• Primary or Secondary: Primary
• Content And Storage: This product contains sodium azide and is stable for 24 months from the date of manufacture when stored at 2-8°C. Do not use after expiration date indicated on label of the product. If reagent is not storedas recommended, performance must be validated by the user

• Cellular Localization: Cytoplasmic
• Clone: 1G12
• Host Species: Mouse
• Molecular Weight of Antigen: ∼60kDa
• Purification Method: Unpurified
• Regulatory Status: IVD
• Target Species: Human
• Isotype: IgG1