Tocris Bioscience™ HC 067047

Potent and selective TRPV4 antagonist

Brand:  Tocris Bioscience™ 4100/50

Product Code. 18045232

Description

HC 067047 is a potent and selective TRPV4 antagonist. Reversibly inhibits currents through mouse, human and rat TRPV4 orthologs (IC50 values are 17, 48 and 133 nM respectively). Also inhibits the endogenous TRPV4-mediated response to 4α-PDH (IC50 = 22 nM). Selective for TRPV4 over TRPV1, TRPV2, TRPV3 and TRPM8 channels.

Specifications

• Chemical Name or Material: 2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
• Quantity: 50 mg
• Molecular Formula: C₂₆H₂₈F₃N₃O₂

• CAS: 883031-03-6
• Target: TRPV Antagonists
• Purity: 0.99