Invitrogen™ Human CD200 His-tag Recombinant Protein

Recombinant Protein

Brand:  Invitrogen™ RP87980

Product Code. 17965831

Description

CD200 is a type-1 membrane glycoprotein that contains two immunoglobulin domains, and belongs to the immunoglobulin superfamily. CD200 is a broadly distributed cell surface glycoprotein that interacts with a receptor on myeloid cells (CD200R) and is implicated in locally preventing macrophage activation. Distant, but recognizable, homologues of CD200 have been identified in many herpesviruses and poxviruses. Studies of the related genes in mouse and rat suggest that CD200 may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms of CD200 have been found. Diseases associated with CD200 dysfunction include Mantle Cell Lymphoma and Primary Hypertrophic Osteoarthropathy.

Specifications

• Accession Number: P41217
• Format: Lyophilized
• Gene ID (Entrez): 4345
• Name: Cd200
• Quantity: 100 μg
• Regulatory Status: RUO
• Gene Alias: antigen identified by monoclonal antibody MRC OX-2; CD200; Cd200 antigen; Cd200 molecule; cell surface protein (thymocyte antigen identified by monoclonal antibody MRC-O x 2); Cspmo2; hypothetical protein LOC534910; MO x 1; MO x 2; MRC; MRC OX-2 antigen; MRCO x 2; My033; O x 2; OX-2; OX-2 membrane glycoprotein
• Product Type: Protein
• Conjugate: Unconjugated
• Sequence: Human CD200, amino acids Met1-Gly232 (Accession # NP_005935.4) with a C-terminal His-tag
• Expression System: HEK293 cells

• For Use With (Application): ELISA
• Formulation: PBS with 0.01% mannitol, 0.01% Tween 80, 5-8% trehalose and no preservative; pH 7.4
• Molecular Weight (g/mol): 40-45 kDa
• Purification Method: SDS-PAGE
• Storage Requirements: -20°C, Avoid Freeze/Thaw Cycles
• Endotoxin Concentration: <1.0 EU/ μg
• Gene Symbol: Cd200
• Specific Reactivity: Human
• Recombinant: Recombinant
• Activity: Immobilized CD200 Protein, Human, Recombinant (His Tag) (at 2 μg/mL (100 μL/well) can bind CD200R Protein, Human, Recombinant (His and hFc Tag), the EC50 is 5-28 ng/mL)
• Purity or Quality Grade: >98% as determined by SDS-PAGE.