Gibco™ Human Heregulin beta-1 Recombinant Protein, PeproTech®

E. coli Recombinant Protein

Brand:  Gibco™ 100-03-100UG

Product Code. 17830953

Description

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.

Specifications

• Accession Number: Q02297
• Formulation: protein with no preservative
• Molecular Weight (g/mol): 7.5
• Quantity: 100 μg
• Storage Requirements: -20°C
• Endotoxin Concentration: <1 EU/μg
• Gene Symbol: Nrg1
• Conjugate: Unconjugated
• Sequence: SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.

• For Use With (Application): ELISA, Functional Assay, Western Blot
• Gene ID (Entrez): 3084
• Name: Human Heregulin beta-1
• Source: E. coli
• Regulatory Status: RUO
• Gene Alias: 6030402G23Rik; acetylcholine receptor-inducing activity; ARIA; Breast cancer cell differentiation factor p45; D230005F13Rik; GGF; GGF2; GGFII; Glial growth factor; glial growth factor 2; heregulin; heregulin, alpha (45 kD, ERBB2 p185-activator); Hgl; HRG; HRG1; HRGA; HRGalpha; MST131; MSTP131; NDF; Neu differentiation factor; neuregulin 1; neuregulin 1 type III beta 3; Neuregulin-1; Nrg1; NRG1-IT2; Pro-neuregulin-1, membrane-bound isoform; pro-NRG1; sensory and motor neuron derived factor; Sensory and motor neuron-derived factor; SMDF; type I neuregulin 1; type III neuregulin 1
• Specific Reactivity: Human
• Recombinant: Recombinant
• Form: Lyophilized