Tocris Bioscience™ I-BET 762

Potent and high affinity BET bromodomain inhibitor; anti-inflammatory; orally bioavailable.

Brand:  Tocris Bioscience™ 6521/25

Product Code. 18094322

Description

I-BET 762 is a potent and high affinity BET bromodomain inhibitor (IC50 = 32.5 - 42.5 nM; Kd = 50.5 - 61.3 nM). Inhibits myeloma cell proliferation. Attenuates transcription of oncogenic MYC and suppresses key inflammatory genes. Exhibits efficacy in a range of oncology and immunoinflammatory models. Displays antiproliferative effect in vitro and in vivo. Orally bioavailable.

Specifications

• Chemical Name or Material: (4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide
• Quantity: 25 mg
• Molecular Formula: C₂₂H₂₂ClN₅O₂

• CAS: 1260907-17-2
• Target: Bromodomain Inhibitors
• Purity: 0.98