Eurofins DiscoverX IKKε Protein, Active

Active, N-terminal FLAG and GST-tagged, recombinant, human IKKε, full length, for use in Kinase Assays.

Brand:  Eurofins DiscoverX 14-926

Product Code. 17300804

Description

IKBKE is a noncanonical I-kappa-B kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. Protects cells against DNA damage-induced cell death.

GenBank NM_014002

Specifications

• Formulation: mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 150 mM NaCl, 10 mM β-glycerophosphate, 1 mM sodium orthovanadate, 1 mM NaF, 28% v/v glycerol, 0.03% Brij-35, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
• Quantity: 10 μg
• Recombinant: Recombinant
• Expression System: Recombinant enzyme expressed in Sf21 insect cells
• Purity or Quality Grade: ≥65%

• Molecular Weight (g/mol): 109 kDa
• Species: Human
• Protein Tag: N-terminal FLAG and N-terminal GST
• Protein Form: Full-length
• Protein: IKKε, active