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Eurofins DiscoverX IKKε Protein, Active
Active, N-terminal FLAG and GST-tagged, recombinant, human IKKε, full length, for use in Kinase Assays.
Brand: Eurofins DiscoverX 14-926
This item is not returnable.
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Description
IKBKE is a noncanonical I-kappa-B kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. Protects cells against DNA damage-induced cell death.
GenBank NM_014002
Specifications
mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 150 mM NaCl, 10 mM β-glycerophosphate, 1 mM sodium orthovanadate, 1 mM NaF, 28% v/v glycerol, 0.03% Brij-35, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. | |
10 μg | |
Recombinant | |
Recombinant enzyme expressed in Sf21 insect cells | |
≥65% |
109 kDa | |
Human | |
N-terminal FLAG and N-terminal GST | |
Full-length | |
IKKε, active |