Indomethacin, 98%, Thermo Scientific Chemicals

Product Code	Brand	Quantity
11496380	Thermo Scientific Alfa Aesar A19910.06	5 g
11406390	Thermo Scientific Alfa Aesar A19910.14	25 g
11416390	Thermo Scientific Alfa Aesar A19910.22	100 g

Description

It is a non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis. It finds its application as gout suppressant, non-steroidal anti-inflammatory drug and analgesic. It also plays many biological roles. Additionally, Indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in acetone (40 mg/mL - clear, yellow solution), ethanol (20 mg/mL), ether, castor oil; Soluble in chloroform (50 mg/mL - clear, yellow, extremely viscous solution); decomposed by strong alkali but stable in neutral or slightly acidic media; insoluble in water.

Notes
Store away from oxidizing agents, strong bases and light. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Chemical Identifiers

• CAS: 53-86-1
• Molecular Weight (g/mol): 357.79
• InChI Key: CGIGDMFJXJATDK-UHFFFAOYSA-N
• PubChem CID: 3715
• IUPAC Name: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

• Molecular Formula: C19H16ClNO4
• MDL Number: MFCD00057095
• Synonym: indomethacin, indometacin, indocin, indometacine, indomethacine, indocid, metindol, amuno, indomethazine, imbrilon
• ChEBI: CHEBI:49662
• SMILES: CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O

Specifications

• CAS: 53-86-1
• Assay Percent Range: 0.98
• MDL Number: MFCD00057095
• Beilstein: 497341
• Merck Index: 14,4968
• Solubility Information: Soluble in acetone (40mg/mL- clear,yellow solution),ethanol (20mg/mL),ether,castor oil; Soluble in chloroform (50mg/mL- clear,yellow,extremely viscous solution); decomposed by strong alkali but stable in neutral or slightly acidic media; insoluble in water.
• SMILES: CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)O
• Molecular Weight (g/mol): 357.79
• ChEBI: CHEBI:49662
• Percent Purity: 98%

• Melting Point: 158°C to 161°C
• Molecular Formula: C19H16ClNO4
• UN Number: UN2811
• Sensitivity: Light sensitive
• Synonym: indomethacin, indometacin, indocin, indometacine, indomethacine, indocid, metindol, amuno, indomethazine, imbrilon
• InChI Key: CGIGDMFJXJATDK-UHFFFAOYSA-N
• IUPAC Name: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid
• PubChem CID: 3715
• Formula Weight: 357.8
• Chemical Name or Material: Indomethacin

Safety and Handling

GHS H Statement
H300-H341

P201-P202-P261-P264b-P270-P272-P280g-P281-P301+P310-P302+P352-P308+P313-P330-P333+P313-P363-P501c

H300-H317-H360FD

missing translation for 'dotInformation' : Hazard Class: 6.1; Packaging Group: II

missing translation for 'einecsNumber' : 200-186-5

missing translation for 'rtecsNumber' : NL3500000

missing translation for 'tsca' : Yes

Recommended Storage : Ambient temperatures

Product Identifier

• Indomethacin

Signal Word

• Danger

Hazard Category

• Acute toxicity Category 1
• Reproductive toxicity Category 1B
• Skin sensitiser Category 1

Hazard Statement

• H300-Fatal if swallowed.
• H317-May cause an allergic skin reaction.
• H360FD-May damage fertility. May damage the unborn child.

Precautionary Statement

• P201-Obtain special instructions before use.
• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
• P302+P352-IF ON SKIN: Wash with plenty of water/soap.
• P308+P313-IF exposed or concerned: Get medical advice/attention.
• P330-Rinse mouth.

Supplemental information

• MIXTURE LIST-Contains : Indomethacin

RUO – Research Use Only