Tocris Bioscience™ J 147

Neuroprotective and neurotrophic compound; reduces Aβ40 and Aβ42 levels

Brand:  Tocris Bioscience™ 5081/10

Product Code. 18793429

Description

J 147 is a potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro (EC50 = 25 - 200 nM). Reduces soluble Aβ40 and Aβ42 levels and increases BDNF levels in the hippocampus in vivo. Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer's disease mice, respectively. Orally active.

Specifications

• Purity: >99%
• Product Type: J 147
• Inhibitors: J 147

• Quantity: 10 mg
• Molecular Weight (g/mol): 350.33

For Research Use Only