Thermo Scientific Chemicals Metronidazole, 99%

Product Code	Brand	Quantity	Packaging
10691063	Thermo Scientific Chemicals 210340050	5 g	Glass bottle
10666792	Thermo Scientific Chemicals 210341000	100 g	Plastic bottle
10678124	Thermo Scientific Chemicals 210345000	500 g	Plastic bottle

Description

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Information

• Metronidazole is a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities and acts against protozoa, anaerobic gram-positive, and anaerobic gram-negative bacteria
• Metronidazole is considered a prodrug that produces nitroso-containing intermediates in the cell that can covalently bind DNA, disrupting helical structure, inducing DNA strand breaks, and inhibiting bacterial nucleic acid synthesis, that results in bacterial cell death

Applications

• Metronidazole shows anti-parasitic and anti-amoebic activities.
• It has been used to prevent the growth of gram-negative anaerobes belonging to the Bacteroides and Fusobacterium, and gram-positive anaerobes such as Peptostreptococcus and Clostridia. This compound affects a high percentage of gram-negative bacteria and has higher tissue penetration that gives it an advantage compared to other compounds.
• This compound was used initially to suppress protozoans such as Entamoeba histolytica, Giardia lamblia, and Trichomonas vaginalis.
• It has been commonly applied for the eradication of Helicobacter pylori.
• It also has a radio-sensitizing effect on hypoxic tumor cells and can have a mutagenic activity in in vivo animal models.

Chemical Identifiers

• CAS: 443-48-1
• Molecular Weight (g/mol): 171.16
• InChI Key: VAOCPAMSLUNLGC-UHFFFAOYSA-N
• PubChem CID: 4173
• IUPAC Name: 2-(2-methyl-5-nitroimidazol-1-yl)ethanol

• Molecular Formula: C₆H₉N₃O₃
• MDL Number: MFCD00009750
• Synonym: metronidazole, metronidazol, flagyl, 2-methyl-5-nitroimidazole-1-ethanol, anagiardil, trichazol, gineflavir, meronidal, metronidaz, novonidazol
• ChEBI: CHEBI:6909
• SMILES: CC1=NC=C(N1CCO)[N+](=O)[O-]

Specifications

• CAS: 443-48-1
• CAS Max %: 100.0
• Color: White to Yellow
• Assay Percent Range: 99%
• MDL Number: MFCD00009750
• Synonym: metronidazole, metronidazol, flagyl, 2-methyl-5-nitroimidazole-1-ethanol, anagiardil, trichazol, gineflavir, meronidal, metronidaz, novonidazol
• InChI Key: VAOCPAMSLUNLGC-UHFFFAOYSA-N
• IUPAC Name: 2-(2-methyl-5-nitroimidazol-1-yl)ethanol
• PubChem CID: 4173
• Formula Weight: 171.16
• Physical Form: Crystalline Powder

• CAS Min %: 98.5
• Melting Point: 159°C to 163°C
• Infrared Spectrum: Authentic
• Molecular Formula: C₆H₉N₃O₃
• Merck Index: 15, 6236
• Solubility Information: Solubility in water: 1g/100mL (20°C). Other solubilities: soluble in diluted acids,0.5g/100mL ethanol- <0.05g/100mL ether (20°C),<0.05g/100mL chloroform (20°C),sparingly soluble in dmf
• SMILES: CC1=NC=C(N1CCO)[N+](=O)[O-]
• Molecular Weight (g/mol): 171.16
• ChEBI: CHEBI:6909
• Percent Purity: 99%
• Chemical Name or Material: Metronidazole

Safety and Handling

GHS H Statement
May cause cancer.

GHS P Statement
Obtain special instructions before use.
Wear protective gloves/protective clothing/eye protection/face protection.
IF exposed or concerned: Get medical advice/attention.

GHS Signal Word: Danger

missing translation for 'einecsNumber' : 207-136-1

Product Identifier

• Metronidazole

Signal Word

• Warning

Hazard Category

• Carcinogenicity Category 1B
• Germ cell mutagenicity Category 2

Hazard Statement

• H341-Suspected of causing genetic defects.
• H350-May cause cancer.
• H412-Harmful to aquatic life with long lasting effects.

Precautionary Statement

• P280-Wear protective gloves/protective clothing/eye protection/face protection.
• P201-Obtain special instructions before use.
• P308+P313-IF exposed or concerned: Get medical advice/attention.

RUO – Research Use Only