Gibco™ Mouse RELM alpha Recombinant Protein, PeproTech®

E. coli Recombinant Protein

Product Code	Brand	Quantity
17834173	Gibco™ 450-26-100UG	100 μg
17814253	Gibco™ 450-26-1MG	1 mg
17864183	Gibco™ 450-26-250UG	250 μg
17844253	Gibco™ 450-26-25UG	25 μg
17804023	Gibco™ 450-26-500UG	500 μg
17853963	Gibco™ 450-26-5UG	5 μg

Description

RELM alpha, also known as Resistin-like alpha or FIZZ1, is a small cytokine (88 aminoacids, MW 9.4 kDa) produced mostly by macrophages. Its highest constitutive expression has been observed in small peritoneal macrophages, alveolar macrophages and adipose tissue macrophages. It is strongly induced by IL-4 and IL-13. Together with Arginase 1 and Ym-1, RELM alpha is considered one of the hallmarks of the M2 polarization of mouse macrophages, however, macrophages polarized with IL-10 (M2c) express neither RELM alpha nor Arginase 1. Also, the expression patterns of RELM alpha and Arginase 1 in untreated tissue macrophages significantly differ. Elevated levels of RELM alpha may indicate parasitic infection. Humans do not have RELM alpha gene but human Resistin resembles mouse RELM alpha in respect to sequence, tissue distribution and function. Other members of RELM family in mouse: RELM beta, RELM gamma and Resistin display different tissue distribution and functional properties. RELM alpha plays an important role in parasite infection, mucosal inflammation and allergy.

Specifications

• Accession Number: Q9EP95
• Formulation: protein with no preservative
• Molecular Weight (g/mol): 10
• Source: E. coli
• Regulatory Status: RUO
• Gene Alias: 1810019L16Rik; cysteine-rich secreted protein A12-gamma; Cysteine-rich secreted protein FIZZ1; Fizz1; Fizz-1; FIZZ2; found in inflammatory zone 1; Himf; HXCP2; Hypoxia-induced mitogenic factor; parasite-induced macrophage novel gene 1 protein; Pmng1; RELMa; RELMalpha; RELM-alpha; RELMb; RELMbeta; RELM-beta; resistin like alpha; resistin-like alpha; Retnla; Xcp2
• Specific Reactivity: Mouse
• Recombinant: Recombinant
• Form: Lyophilized

• For Use With (Application): ELISA, Functional Assay, Western Blot
• Gene ID (Entrez): 57262
• Name: Mouse RELM alpha
• Storage Requirements: -20°C
• Endotoxin Concentration: <1 EU/μg
• Gene Symbol: Retnla
• Conjugate: Unconjugated
• Sequence: MDETIEIIVE NKVKELLANP ANYPSTVTKT LSCTSVKTMN RWASCPAGMT ATGCACGFAC GSWEIQSGDT CNCLCLLVDW TTARCCQLS
• Purity or Quality Grade: ≥ 98% by SDS-PAGE gel and HPLC analyses.