MP Biomedicals™ Collagenase from Clostridium histolyticum

Enzyme responsible for break down of peptide bonds in collagen.

Brand:  MP Biomedicals™ 02195109.1

Product Code. 11470972

Description

Assist in destroying extracellular structures in pathogenesis of bacteria such as Clostridium. These enzymes are exotoxins (a virulence factor) and help to facilitate the spread of gas gangrene. They normally target the connective tissue in muscle cells and other body organs. 

• Synonyms: Clostridiopeptidase A
• CAS Number: 9001-12-1
• EC Number: 232-582-9
• MDL Number: MFCD00130830
• Format: Dialyzed, lyophilized brown lumpy powder
• Specific Activity: >125U/mg
• Solubility: Dissolve enzyme at concentration of 1mg/mL in 0.05M TES with 0.36mM calcium chloride, pH 7.5 

Note: This item is for research use only.  It is not a compendial item and is not meant for medical use.

Specifications

• Concentration: >125 U/mg
• pH: 7 to 9
• Source: Clostridium histolyticum
• Product Type: Collagenase
• Inhibitors: Metal chelating agents such as Cysteine, EDTA or o-Phenanthroline

• Color: Brown
• Content And Storage: 4°C
• Quantity: 100 mg
• Molecular Weight (g/mol): 105000 and 57400
• Form: Lyophilized Powder

Safety and Handling

Product Identifier

• Collagenase, Type I

Signal Word

• Danger

Hazard Category

• Serious eye damage/eye irritation Category 2
• Respiratory sensitiser Category 1
• Skin corrosion/irritation Category 2
• Skin sensitiser Category 1
• Specific target organ toxicity Category 3

Hazard Statement

• H315-Causes skin irritation.
• H317-May cause an allergic skin reaction.
• H319-Causes serious eye irritation.
• H334-May cause allergy or asthma symptoms or breathing difficulties if inhaled.
• H335-May cause respiratory irritation.

Precautionary Statement

• P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
• P284-¢In case of inadequate ventilation! wear respiratory protection.
• P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
• P321-Specific treatment (see on this label).
• P405-Store locked up.
• P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.

Supplemental information

• MIXTURE LIST-Contains : collagenase

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