Tocris Bioscience™ MZ 1

(+)-JQ1 based Degrader (PROTAC™) that selectively degrades BRD4

Brand:  Tocris Bioscience™ 6154/5

Product Code. 18749718

Description

Cell penetrant Degrader (PROTAC®) compound based on (+)-JQ1 (Cat.No. 4499) conjugated to a von Hippel-Lindau (VHL) ligand. MZ 1 retains high affinity for BRD2, BRD3 and BRD4 bromodomains (Kd = 13-60 nM) but induces preferential degradation of BRD4 over BRD2 and BRD3 (DC50 values for degradation of BRD4 are 8 and 23 nM in H661 and H838 cells, respectively). Exhibits potent cytotoxicity and antiproliferative effects in AML cell lines (pEC50 = 7.6 in Mv4-11 cells).

Negative control cis MZ 1 also available.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Specifications

• Product Type: Cell Degrader
• CAS: 1797406-69-9
• Formula Weight: 1002.64g/mol
• For Use With (Application): Bromodomain Inhibitors

• Target Proteins: Bromodomain
• Molecular Formula: C₄₉H₆₀ClN₉O₈S₂
• Content And Storage: Store at -20°C
• Quantity: 5 mg

For Research Use Only