Tocris Bioscience™ NAV 2729

Selective ARF6 inhibitor

Brand:  Tocris Bioscience™ 5986/50

Product Code. 18755999

Description

NAV 2729 is a selective ARF6 inhibitor (IC50 = 1.0 μM). Selective for ARF6 over other ARF family members and small GTPases. Inhibits ARF6 activation in uveal melanoma cells in vitro and blocks downstream signaling pathways of oncogenic GNAQ. Reduces tumorigenesis in mouse model of uveal melanoma.

Specifications

• Color: Yellow
• CAS: 419547-11-8
• Formula Weight: 456.88g/mol
• Content And Storage: Store at 4°C
• Quantity: 50 mg

• Product Type: Inhibitor
• Molecular Formula: C₂₅H₁₇ClN₄O₃
• Solubility: Soluble to 100mM in DMSO
• For Use With (Application): Blocks downstream signaling pathways

For Research Use Only