CellSensor™ NFAT-bla RA-1 Cell Line

CellSensor™ NFAT-bla RA-1 Cell Line is important for B cell proliferation and differentiation.

Brand:  CellSensor™ K1490

Product Code. 10318824

Description

• B cell receptor (BCR)-mediated signaling pathways are important for B cell proliferation and differentiation.
• Abnormal B cell signaling has been linked to various diseases such as lupus, lymphoma, and various immune disorders.
• Antigen binding to the BCR promotes the activation of several protein tyrosine kinases (PTK), which leads to phosphorylation of the BCR complex and recruitment and activation of the PTK Syk.
• This in turn promotes phosphorylation of PLCγ, Shc, and Vav. Additionally, the Tec family member Btk is recruited to the plasma membrane, where it is involved in activation of PLCγ.
• Initiation of B lymphocyte activation is dependent on the tyrosine phosphorylation-dependent formation of multimolecular effector protein complexes that activate downstream signaling pathways including PKC/Ca2+/NFAT.
• This cell-based assay has been thoroughly tested and validated by Invitrogen and is suitable for immediate use in screening applications.

Specifications

• Content And Storage: Store in liquid nitrogen immediately upon receipt, or thaw for immediate use
• For Use With (Application): Signaling Pathway
• Type: Dividing Cells

• Detection Method: Fluorescent
• Quantity: 1 Vial