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Oncrasin 1, Tocris Bioscience™
Induces abnormal nuclear aggregation of PKCι; proapoptotic
£104.03 - £376.27
Chemical Identifiers
CAS | 75629-57-1 |
---|---|
Molecular Formula | C16H12ClNO |
Molecular Weight (g/mol) | 269.73 |
MDL Number | MFCD01051808 |
InChI Key | ZDRQMXCSSAPUMM-UHFFFAOYSA-N |
Synonym | oncrasin-1, 1-4-chlorobenzyl-1h-indole-3-carbaldehyde, oncrasin 1, 1-4-chlorophenyl methyl indole-3-carbaldehyde, 1-4-chlorophenyl methyl-1h-indole-3-carboxaldehyde, 1-4-chloro-benzyl-1h-indole-3-carbaldehyde, oncrasin1, cambridge id 5601604, n-4-chlorobenzyl-3-formylindole, oncrasin hplc |
PubChem CID | 872445 |
IUPAC Name | 1-[(4-chlorophenyl)methyl]-1H-indole-3-carbaldehyde |
SMILES | ClC1=CC=C(CN2C=C(C=O)C3=CC=CC=C23)C=C1 |
Description
Proapoptotic agent that induces abnormal nuclear aggregation of PKCι and suppresses RNA transcription. Exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC50 ≤ 3 μM) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo.Chemical Identifiers
75629-57-1 | |
269.73 | |
ZDRQMXCSSAPUMM-UHFFFAOYSA-N | |
872445 | |
ClC1=CC=C(CN2C=C(C=O)C3=CC=CC=C23)C=C1 |
C16H12ClNO | |
MFCD01051808 | |
oncrasin-1, 1-4-chlorobenzyl-1h-indole-3-carbaldehyde, oncrasin 1, 1-4-chlorophenyl methyl indole-3-carbaldehyde, 1-4-chlorophenyl methyl-1h-indole-3-carboxaldehyde, 1-4-chloro-benzyl-1h-indole-3-carbaldehyde, oncrasin1, cambridge id 5601604, n-4-chlorobenzyl-3-formylindole, oncrasin hplc | |
1-[(4-chlorophenyl)methyl]-1H-indole-3-carbaldehyde |
Specifications
75629-57-1 | |
MFCD01051808 | |
ZDRQMXCSSAPUMM-UHFFFAOYSA-N | |
1-[(4-chlorophenyl)methyl]-1H-indole-3-carbaldehyde | |
872445 | |
>98% |
C16H12ClNO | |
oncrasin-1, 1-4-chlorobenzyl-1h-indole-3-carbaldehyde, oncrasin 1, 1-4-chlorophenyl methyl indole-3-carbaldehyde, 1-4-chlorophenyl methyl-1h-indole-3-carboxaldehyde, 1-4-chloro-benzyl-1h-indole-3-carbaldehyde, oncrasin1, cambridge id 5601604, n-4-chlorobenzyl-3-formylindole, oncrasin hplc | |
ClC1=CC=C(CN2C=C(C=O)C3=CC=CC=C23)C=C1 | |
269.73 | |
269.73 | |
Oncrasin 1 |
Safety and Handling
Recommended Storage : Store at +4°C