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Tocris Bioscience™ Ozanimod
Potent and selective S1P1 and S1P5 agonist
Brand: Tocris Bioscience™ 7663/50
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Description
Ozanimod is a potent and selective sphingosine-1-phosphate receptor 1 (S1P1) and 5 (S1P5) agonist (EC50 values are 0.41 and 11 nM, respectively, in a [35S]-GTPγS assay). Ozanimod exhibits 27-fold selectivity over S1P5, and >10,000-fold selectivity over S1P2-4. In vitro, Ozanimod induces sustained S1P1 receptor internalization and degradation in S1P1 receptor-HEK293T cells. In vivo, Ozanimod reduces inflammation and disease parameters in rat models of autoimmune disease. Ozanimod reduces chronic inflammation and alleviates kidney pathology in a murine model of systemic lupus erythematosus. Ozanimod is orally bioavailable.Specifications
5-[3-[(1 S)-2,3-Dihydro-1-[(2-hydroxyethyl)amino]-1 H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile | |
50 mg | |
C23H24N4O3 |
1306760-87-1 | |
Sphingosine-1-phosphate Receptor Agonists | |
0.98 |