missing translation for 'onlineSavingsMsg'
Learn More
Learn More
Tocris Bioscience™ Ozanimod
Potent and selective S1P1 and S1P5 agonist
£122.03 - £475.15
Specifications
| Chemical Name or Material | 5-[3-[(1 S)-2,3-Dihydro-1-[(2-hydroxyethyl)amino]-1 H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile |
|---|---|
| CAS | 1306760-87-1 |
| Target | Sphingosine-1-phosphate Receptor Agonists |
| Molecular Formula | C23H24N4O3 |
| Purity | 0.98 |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
18766096
|
Tocris Bioscience™
7663/10 |
10 mg |
£122.03
10mg |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
|
18768636
|
Tocris Bioscience™
7663/50 |
50 mg |
£475.15
50mg |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
Ozanimod is a potent and selective sphingosine-1-phosphate receptor 1 (S1P1) and 5 (S1P5) agonist (EC50 values are 0.41 and 11 nM, respectively, in a [35S]-GTPγS assay). Ozanimod exhibits 27-fold selectivity over S1P5, and >10,000-fold selectivity over S1P2-4. In vitro, Ozanimod induces sustained S1P1 receptor internalization and degradation in S1P1 receptor-HEK293T cells. In vivo, Ozanimod reduces inflammation and disease parameters in rat models of autoimmune disease. Ozanimod reduces chronic inflammation and alleviates kidney pathology in a murine model of systemic lupus erythematosus. Ozanimod is orally bioavailable.Specifications
| 5-[3-[(1 S)-2,3-Dihydro-1-[(2-hydroxyethyl)amino]-1 H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile | |
| Sphingosine-1-phosphate Receptor Agonists | |
| 0.98 |
| 1306760-87-1 | |
| C23H24N4O3 |
Safety and Handling
Recommended Storage : Store at -20°C