Tocris Bioscience™ Ozanimod

Potent and selective S1P1 and S1P5 agonist

Brand:  Tocris Bioscience™ 7663/50

Product Code. 18768636

Description

Ozanimod is a potent and selective sphingosine-1-phosphate receptor 1 (S1P1) and 5 (S1P5) agonist (EC50 values are 0.41 and 11 nM, respectively, in a [35S]-GTPγS assay). Ozanimod exhibits 27-fold selectivity over S1P5, and >10,000-fold selectivity over S1P2-4. In vitro, Ozanimod induces sustained S1P1 receptor internalization and degradation in S1P1 receptor-HEK293T cells. In vivo, Ozanimod reduces inflammation and disease parameters in rat models of autoimmune disease. Ozanimod reduces chronic inflammation and alleviates kidney pathology in a murine model of systemic lupus erythematosus. Ozanimod is orally bioavailable.

Specifications

• Chemical Name or Material: 5-[3-[(1 S)-2,3-Dihydro-1-[(2-hydroxyethyl)amino]-1 H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile
• Quantity: 50 mg
• Molecular Formula: C₂₃H₂₄N₄O₃

• CAS: 1306760-87-1
• Target: Sphingosine-1-phosphate Receptor Agonists
• Purity: 0.98