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DiscoverX PathHunter™ eXpress c-Ret-GFRα2 Functional Assay

Product Code. 17343839
Encompass
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Quantity:
1,000 dp (10 x 96-well)
Unit Size:
1 set
This item is not returnable. View return policy

Product Code. 17343839

Brand: DiscoverX 930816E3CP16L

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This item is not returnable. View return policy

Description

The PathHunter™ eXpress c-Ret-GFRα2 Functional Assay measures c-Ret-GFRα2 receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. eXpress kits contain all assay materials: cells, reagents, and plates. Cyno version.

The PathHunter™ eXpress c-Ret-GFRα2 Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated c-Ret and GFRα2 dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cells overexpress PK-tagged c-Ret and an EA-tagged SH2 domain protein. It also overexpresses an untagged coreceptor, GFRα2 Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. Please note that this product expresses the Cyno version of the protein.

Specifications

Assay Entry Kinase
For Use With (Application) Assay-Ready eXpress Kits
Quantity 1,000 dp (10 x 96-well)
Target Entry c-Ret-GFRα2
Target c-Ret-GFRα2
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