Tocris Bioscience™ PD 98059

MEK inhibitor

Brand:  Tocris Bioscience™ 1213/10

Product Code. 18708126

Description

PD 98059 is an inhibitor of mitogen-activated protein kinase kinase (MKK/ MEK). Acts by binding to the inactivated form of MEK, thereby preventing its phosphorylation by cRAF or MEK kinase (IC50 = 2-7 μM). Inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines; causes G1 arrest by blocking p53-dependent p21 induction. Enhances embryonic stem cell self-renewal.

Specifications

• Purity: 98%
• CAS: 167869-21-8
• Quantity: 10 mg
• Molecular Weight (g/mol): M.W. (Observed): 267.28

• Molecular Formula: 2-(2-Amino-3-methoxyphenyl)-4 H-1-benzopyran-4-one
• Content And Storage: Room Temperature
• Product Type: PD 98059
• Inhibitors: PD 98059

For Research Use Only